By R. J. Hay (auth.), R. J. Hay MD, MRCP, MRCPath. (eds.)
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Additional resources for Advances in Topical Antifungal Therapy
Example text
53 Introduction Unlike the treatment of vaginal mycoses, the treatment of dermatomycoses has the disadvantage that the majority of therapeutic agents still require application for 4 to 6 weeks or longer, depending on the agent chosen. The result of this long duration oftherapy is inadequate compliance and, in consequence, premature termination of treatment and a high rate of recurrence. In a survey among dermatologists and patients, Meinhof et al. found that about 50% of patients paid no attention to medical directions about the frequency of application, 44% reduced the number of applications without being told to do so and 25% stopped treatment as soon as the symptoms had disappeared.
The fluorescent microscopy showed hyphae with septa and spores that stained a brilliant light green against a black background. The mycelial elements and spores of Candida and Pityriasis versicolor stained as well as dermatophyte hyphae. The stain was immediately taken up by the fungal cell walls and septa which made it possible to read the results directly after the staining procedure. Photomicrographs of dermatophyteinfected scales as well as of specimens from candido sis of the oral and vaginal mucosa are shown (Figs.
Frequency of diagnosis (n = 5057) Diagnosis n Tinea corporis / Tinea cruris Tinea pedis interdigitalis Superficial candidosis Pityriasis versicolor 1970 1918 537 56 628 the investigators, and 1627 trial protocols were completed and analysed. In my presentation of the therapeutic results I will summarise the findings obtained with the two dosage forms. This is possible as the courses of treatment in the two patient groups differed only slightly. Duration of Treatment As I mentioned in the introduction, the actual duration of treatment was of particular interest to us.