By Robert Klitzman
Within the fifty years considering the fact that DNA was once came upon, we've seen striking advances. for instance, genetic checking out has speedily more advantageous the analysis and remedy of ailments resembling Huntington's, cystic fibrosis, breast melanoma, and Alzheimer's. yet with this new wisdom comes tricky judgements for numerous humans, who strive against with worry approximately no matter if to get validated, and if that is so, what to do with the consequences. Am I My Genes? exhibits how actual participants have faced those concerns of their day-by-day lives.
Robert L. Klitzman interviewed sixty four those who confronted Huntington's ailment, breast and ovarian melanoma, or Alpha-1 antitrypsin deficiency. The e-book describes--often within the person's personal words--how each one has wrestled with the colossal implications that genetics has for his or her lives and their households. Klitzman exhibits how those women and men fight to make feel in their hindrance and its explanations. They confront a chain of quandaries--whether to be verified; no matter if to reveal their genetic dangers to folks, siblings, spouses, offspring, pals, medical professionals, insurers, employers, and colleges; how one can view and comprehend themselves and their genetics; what remedies, if any, to pursue; no matter if to have little ones, undertake, monitor embryos, or abort; and even if to take part in genetic groups. within the face of those uncertainties, they've got attempted to appreciate those assessments and possibilities, keep away from fatalism, nervousness, depression, and discrimination, and locate desire, which means, and a feeling of wholeness. pressured to wander via a desolate tract of moving sands, they chart paths that many others may perhaps finally keep on with.
Klitzman captures the following the voices of pioneers, many of the first to come across the private dilemmas brought through sleek genetics. Am I My Genes? is a useful account in their event, one who turns into all of the extra universal within the coming years.
"An notable exploration...probing the numerous roles and implications of genetics in our lives today.... full of unbelievable insights, this riveting booklet is key interpreting for us all." -- Paula Zahn
"Klitzman lucidly discusses the ethical and mental complexities that are available the wake of genetic testing.... a massive booklet for somebody who has the genes for pathology, that's we all, and that i suggest it highly." -- Kay Redfield Jamison, writer of An Unquiet brain
"An illuminating voyage in the course of the scientific, familial and existential quandaries confronted via these people at genetic risk." -- Thomas H. Murray, President and CEO, The Hastings middle Show
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Additional info for Am I My Genes?: Confronting Fate and Family Secrets in the Age of Genetic Testing
Cannabinoid Receptor 1 (CNR1) Cannabinoid receptors have been implicated in movement disorders and are downregulated in Huntington’s disease, whereas upregulation is observed in Parkinson’s disease . Based on the mentioned observations, cannabinoid-based drugs targeting the cannabinoid-signalling systems are believed to alleviate motor symptoms  and make cannabinoid receptors ideal genes to be studied in the context of TD. A study by Tiwari et al.  has investigated the role of CNR1 gene and TD; 26 M.
The most clinically relevant finding was obtained in MC4R homozygote carriers for rs489693 who on average gained twice as much weight than noncarriers. In addition to other risk variants, such as HTR2C, polygenic risk tests for AIWG might become available for use in clinical practice. As for CIA, a few studies have been conducted in the past years linking CIA further to immunological system genes. These findings suggest that gene variants associated with CIA might show relatively large effect sizes such as the HLAB*15:02 allele which is associated with an increased risk of carbamazepine-induced Stevens-Johnson syndrome .
Zhang XY, Tan YL, Zhou DF, Haile CN, Cao LY, Xu Q, Shen Y, Kosten TA, Kosten TR (2007) Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population. J Clin Psychopharmacol 27(3):246–251 Chapter 3 Pharmacogenetics of the Efficacy and Side Effects of Antidepressant Drugs Chiara Fabbri and Alessandro Serretti Abstract Both major depressive disorder (MDD) and antidepressant drug efficacy show an established evidence of being significantly affected by genetic polymorphisms.