Download PDF by Jacques Descotes: An introduction to immunotoxicology

By Jacques Descotes

Lyon-RTH Laennec college of medication, France. creation to key immunotoxicological concerns. Considers the overall healthiness results of immunotoxicity and addresses the cutting-edge equipment used to realize and assessment unforeseen immunotoxic results of xenobiotics, either preclinically and clinically. For undergraduate and graduate scholars. Hardcover, softcover additionally to be had.

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P. (1990) Iatrogenic immunodeficiencies. Curr. Op. , 2, 445–450. D. P. (1995) The primary immunodeficiencies. N. Engl. J. , 333, 431–440. H. (1993) Impact of cytomegalovirus infection on organ transplant recipients. Rev. Infect. , 12, S754–S766. H. S. (1994) Clinical Approach to Infection in the Compromised Host, 3rd edition. New York: Plenum Medical. H. C. (1997) Infectious complications of immunosuppressive therapy in patients with rheumatic diseases. Rheum. Dis. Clin. N. , 23, 219–237. , et al.

D. (1990) Drug interactions involving immunologic agents. Part I. Vaccinevaccine, vaccine-immunoglobulin, and vaccine drug interactions. DICP, Ann. , 24, 67–81. W. R. (1983) Depression of theophylline elimination following BCG vaccination. Br. J. Clin. , 16, 735–737. , et al. (1989) Effects of interferon-a on theophylline pharmacokinetics and metabolism. Br. J. Clin. , 27, 795–802. KOREN, G. and GREENWALD, M. (1985) Decrease in theophylline clearance causing toxicity during viral epidemics. J. Asthma, 22, 75–79.

The development of infectious complications in exposed individuals is indeed much more convincing evidence of the immunotoxic role of the chemical exposure under consideration, than the finding of immune function changes and still more so, than merely descriptive alterations of the normal architecture of selected lymphoid organs. The use of experimental infection models is therefore logical in immunotoxicity evaluation, but these models must be carefully selected to evidence the adverse consequences of unexpected immunosuppression related to chemical exposure.

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