Download e-book for iPad: Andrology: Male Reproductive Health and Dysfunction by Eberhard Nieschlag, Hermann M. Behre, Susan Nieschlag

By Eberhard Nieschlag, Hermann M. Behre, Susan Nieschlag

This can be the third, absolutely revised version of a well known textbook that keeps to symbolize the most reliable within the literature on scientific andrology. It examines extensive all elements of male reproductive well-being, encompassing the fundamental body structure of male reproductive functionality and a variety of issues. all the chapters is written through amazing specialists within the box. one of the themes lined are: Testicular functionality, sperm maturation and fertilization, diagnostic approaches, infertility, basic and secondary hypogonadism, late-onset hypogonadism, erectile disorder, genetic problems, environmental affects, psychology and sexual medication, testosterone remedy, assisted replica: TESE and ICSI, cryopreservation, male birth control and ethics in andrology.

This quantity will function a textbook for the newcomer to andrology, whereas supplying the skilled health practitioner with a priceless reference paintings. it is going to attract all who're eager about male reproductive health.

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Example text

And β subunits are non-covalently linked and the probable tertiary structure of pituitary gonadotropins can be approximated and deduced by analogy with its cognate hCG, whose crystal structure has been resolved. LH and hCGβ subunits are structurally very similar and, in fact, LH and hCG act on the same receptor. A peculiar feature of hCGβ is a carboxyl-terminal extension containing four O-linked sugar residues that remarkably reduces the rate of metabolism and increases the half-life of the hormone.

Primate sperm production is controlled through the number of spermatogonia entering meiosis. Programmed cell death (apoptosis) comprises a coordinated sequence of signalling cascades leading to cell suicide. Unlike necrosis, this form of cell death occurs under physiological conditions (spontaneous apoptosis) but can also be induced by exposure to toxicants, disturbances of the endocrine milieu, etc. In the human testis spermatogonia, spermatocytes and spermatids undergoing apoptosis have been detected and ethnic differences in the incidence of testicular apoptosis have been suggested.

2008). 3 Mechanism of Action of Gonadotropins LH and FSH exert their function via specific receptors (Simoni et al. 1997). The gonadotropin receptors also belong to the family of the G protein-coupled receptors and are characterized by a very large extracellular domain to which the hormone binds specifically, the usual membrane-spanning domain including 7 hydrophobic segments connected to each other through three extracellular and three intracellular tracts, and an intracellular carboxyterminal domain (Fig.

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