Download PDF by Sudhir Agrawal: Antisense Therapeutics

By Sudhir Agrawal

Major researchers supply an authoritative survey and research of the most recent findings at the speedy improvement of antisense oligonucleotides healing and their program in quite a few in vivo version platforms. The book's high-profile individuals offer well timed debts in their cutting-edge ideas, discussing such subject matters because the synthesis and purification of oligonucleotides, their choice for a specific gene goal, assorted tools of management, and using quite a few cellphone traces and phone tradition platforms. in addition they learn questions of mobile uptake, in vitro organic task, in vivo organic task, the pharmacology and pharmacokinetics of oligonucleotides, and the appliance of oligonucleotides to the principal worried procedure.

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8) Circulating lymphocytes and granulocytes expressed a low level of ICAM-1, which was not significantly affected by carrageenan or the 34 Bennett antisense ohgonucleotide treatments (Fig. 2. Cardac A/log-aft et al. 5) The effects of the murine ICAManttsense ohgonucleotrde m a heterotopic cardiac allograft model were evaluated (61). Treatment of C3H recipients of C57BL/lO hearts wtth the ICAM- 1 antisense oligonucleottde resulted in a dosedependent increase m allograft survival (6Z). 7 d for untreated animals.

Antrvzral Res 16, 121-133. 42. Dolmck, B. J. (1991) Antisense agents m cancer research and therapeutics. Cancer Invest 9, 185-l 94 43 Agrawal, S. (1992) Antisense oligonucleotides as antiviral agents TZBTECZf 10, 152-158 44 Bennett, C. F. (1993) Antisense oligonucleotides in inflammation research and therapeutics, in Antisense Research and Applications (Crooke, S. T. and Lebleu, B , eds ), CRC, Boca Raton, pp. 547-562. 44 Bennett et al. , eds ), CRC, Boca Raton, m press 46 Springer, T. A (1990) Adhesion receptors of the immune system.

7 mm. 5 min. This value is consistent with previously published data on inulin clearance out of CSF (9). Given that phosphorothtoate ODN appears stable in the presence of bram tissue, we examined phosphorothioate ODN penetration into bram by direct fluorescence microscopy. Paraformaldehyde-fixed frozen sections were prepared from rat brains 30 mm after bolus intraventrtcular injection of 40 nmol of a fluorescem-labeled phosphorothtoate ODN. Analysis of these frozen sections demonstrated a readily detectable tissue signal.

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