Download e-book for kindle: Apoptosis in Neurobiology (Frontiers in Neuroscience) by Yusuf A. Hannun, Rose-Mary Boustany

By Yusuf A. Hannun, Rose-Mary Boustany

The speedy progress of the research of apoptosis-mechanism-driven, regulated mobilephone death-has created an pressing desire for trustworthy documentation of the various ways to and strategies of learning a number of the facets of the sphere. Apoptosis in Neurobiology is a crucial source for researchers during this rising frontier of biomedical research. This quantity permits the uninitiated neuroscientist highbrow and sensible entry to the research of apoptosis, with detailed attention to the apprehensive procedure. the 1st part concentrates on conceptual methods to the research of apoptosis in neurobiology and its value to the anxious procedure. the second one part offers a ordinary method of tools and strategies within the examine of apoptosis as utilized to neurobiology.

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M. , Overexpression of Bcl-2 or Bcl-XL transgenes and photoreceptor degeneration, Invest. Ophthalmol. Vis. , 37, 2434, 1996. 44. Rich, K. , Zhan, Y. and Blanks, J. , Aberrant expression of c-Fos accompanies photoreceptor cell death in the rd mouse, J. , 32, 593, 1997. 45. , Reed, J. C. , Up-regulation of Bax protein in degenerating retinal ganglion cells precedes apoptotic cell death after optic nerve lesion in the rat, Eur. J. , 9, 1763, 1997. 46. , Lewis, G. , Fisher, S. K. , Apoptotic photoreceptor degeneration in experimental retinal detachment, Invest.

56, 150, 1997. 36. Chang, G. , Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice, Neuron, 11, 595, 1993. 37. Lolley, R. , The rd gene defect triggers programmed rod cell death, Invest. Ophthalmol. Vis. , 35, 4182, 1994. 38. , Sung, C. , Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa, Proc. Natl. Acad. Sci. , 91, 974, 1994. 39. Lolley, R. , and Craft, C. , Linkage of photoreceptor degeneration by apoptosis with inherited defect in phototransduction, Invest.

Apoptosis is the mechanism of neurodegeneration in Batten disease, J. , 67, 677, 1996. 29. , Upregulation of Bcl-2 and elevation of ceramide in Batten disease, Neuropediatrics, 28, 37, 1997. 30. , CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide, 1998, in press. 31. , Reboullet, S. , Identification and characterization of a spinal muscular atrophy-determining gene, Cell, 80, 155, 1995. 32. , Kang, X. , The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy, Cell, 80, 167, 1995.

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