By Andrew W. Zimmerman
Creative considering and collaborative medical examine have complicated our realizing of autism, and we're now commencing to synthesize the information into facts and theories. Autism: present Theories and proof provides present theories approximately autism and the facts that helps them. The objective is to teach how the medical approach is revealing the organic bases of this spectrum of problems, thereby top the right way to their therapy and prevention utilizing evidence-based medication. This publication has 20 chapters divided into 6 sections: Molecular and scientific Genetics; Neurotransmitters and telephone Signaling; Endocrinology, development and Metabolism; Immunology, Maternal-Fetal results and Neuroinflammation; Neuroanatomy, Imaging and Neural networks; and Environmental Mechanisms and versions. the themes conceal quite a lot of present medical paintings within the box of autism, with robust and growing to be proof to help them, and display either the breadth and intensity of present autism study. The reader is inspired to think about how theories and the medical procedure, within the fingers of those and different devoted researchers, are resulting in better wisdom and persisted development in autism research.
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Extra resources for Autism : current theories and evidence
130(20): p. 4881–93. 58. , and Joyner, A. , Fgf8 Can Activate Gbx2 and Transform Regions of the Rostral Mouse Brain into a Hindbrain Fate. Development, 1999. 126(21): p. 4827–38. 59. Liu, A. and Joyner, A. , En and Gbx2 Play Essential Roles Downstream of Fgf8 in Patterning the Mouse Mid/Hindbrain Region. Development, 2001. 128(2): p. 181–91. 60. Morales, D. and Hatten, M. , Molecular Markers of Neuronal Progenitors in the Embryonic Cerebellar Anlage. J Neurosci, 2006. 26(47): p. 12226–36. 61. Fink, A.
In addition to abnormal biochemical markers of compartmentalization, the En2 KO mouse cerebellum exhibits absent bands of expression of the Purkinje cell-specific L7/Pcp, most notably in the hypomorphic lobes of the posterior cerebellum. These disordered and lost compartmental markers suggest that subpopulations of Purkinje cells may be more susceptible to abnormal En2 expression; these subpopulation differences may provide insight into patterns of Purkinje cell loss in humans with ASD . By extension, this would suggest that functionally distinct cerebellar domains may be more susceptible to genetic perturbation and thus contribute to an ASD phenotype.
Smith, R. , Magnetic Resonance Imaging and Head Circumference Study of Brain Size in Autism: Birth Through Age 2 Years. Arch Gen Psychiatry, 2005. 62(12): p. 1366–76. 7. Sparks, B. , Friedman, S. , Shaw, D. , Aylward, E. , Artru, A. , Maravilla, K. , Giedd, J. , and Dager, S. , Brain Structural Abnormalities in Young Children with Autism Spectrum Disorder. Neurology, 2002. 59(2): p. 184–92. 8. Bauman, M. L. and Kemper, T. , Neuroanatomic Observations of the Brain in Autism: A Review and Future Directions.