Read e-book online Biological Concepts and Techniques in Toxicology: An PDF

By Jim E. Riviere

Highlighting the most recent advances in molecular biology, mathematical modeling, quantitative threat overview, and biopharmaceutical improvement, this reference provides how present clinical purposes and techniques impression and revolutionize mainstream toxicological learn. featuring findings from disciplines that would effect the way forward for toxicology in years yet to come together with proteomics, toxicogenomics, and metabonomics, this expertly conceived consultant explores toxicological problems with specific international curiosity, corresponding to toxicity of nanomaterials, army jet fuels, and genetically-modified meals.

Show description

Read Online or Download Biological Concepts and Techniques in Toxicology: An Integrated Approach PDF

Best toxicology books

Download e-book for kindle: Introduction to Systems Biology by Sangdun Choi

This booklet presents an introductory textual content for undergraduate and graduate scholars who're drawn to complete organic structures. The authors supply a wide evaluation of the sphere utilizing key examples and average ways to experimental layout. the quantity starts off with an creation to platforms biology after which info experimental omics instruments. different sections introduce the reader to demanding computational methods. the ultimate sections supply principles for theoretical and modeling optimization in systemic organic researches. The booklet is an necessary source, offering a primary glimpse into the cutting-edge in structures biology.

Download PDF by Katsuhiko Mikoshiba, Abel Lajtha: Handbook of Neurochemistry and Molecular Neurobiology:

This quantity of the guide of Neurochemistry and Molecular Biology makes a speciality of molecular occasions thinking about synapse formation, synaptic plasticity and ongoing neural task. the quantity explores axonal development cones, synapse improvement, and mechanisms of LTP and LTD, and calcium dynamics. specific recognition is given to operate and trafficking of membrane proteins together with a variety of ion channels, aquaporines, hole junctions.

Download e-book for kindle: Endogenous Toxins: Targets for Disease Treatment and by Peter J. O'Brien, William Robert Bruce

Designed as a first-stop reference for researchers and pros in toxicology, pharmacology and drugs, this guide is the first actual to tie jointly the information from many disciplines that has to this point been to be had merely from generally dispersed assets within the fundamental literature. As such, it provides the total photograph on what's at the moment identified approximately endogenous pollutants, together with their new release, mode of motion, ensuing ailment situation, and on hand countermeasures.

Environmental Toxicology Assessment by Mervyn Richardson PDF

Dimension of the level of the poisonous insult because of the substance concerned is of significance whilst project an environmental toxicology evaluate. this article outlines many of the size strategies which were lately constructed and

Additional info for Biological Concepts and Techniques in Toxicology: An Integrated Approach

Example text

Toxicogenomics: Gene Expression Analysis and Computational Tools 23 45. Li L, Darden TA, Weinberg CR, Levine AJ, Pedersen LG. Gene assessment and sample classification for gene expression data using a genetic algorithm/k-nearest neighbor method. Comb Chem High Throughput Screen 2001; 4:727–739. 46. Li L, Weinberg CR, Darden TA, Pedersen LG. Gene selection for sample classification based on gene expression data: study of sensitivity to choice of parameters of the GA/ KNN method. Bioinformatics 2001; 17:1131–1142.

Nat Genet 1999; 21:20–24. 27. gov/microarray/. 28. Nuwaysir EF, Bittner M, Trent J, Barrett JC, Afshari CA. Microarrays and toxicology: the advent of toxicogenomics. Mol Carcin 1999; 24:153–159. 29. gov/DIR/Microarray. 30. Chen Y, Dougherty ER, Bittner ML. Ratio-based decisions and the quantitative analysis of cDNA microarray images. J Biomed Opt 1997; 2:364–374. 31. Chen Y, Kamat V, Dougherty ER, Bittner ML, Meltzer PS, Trent JM. Ratio statistics of gene expression levels and applications to microarray data analysis.

6. Brown PO, Botstein D. Exploring the new world of the genome with DNA microarrays. Nat Genet 1999; 21:33–37. 7. Bowtell DD. Options available—from start to finish—for obtaining expression data by microarray. Nat Genet 1999; 21:25–32. 8. Waring JF, Jolly RA, Ciurlionis R, et al. Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles. Toxicol Appl Pharmacol 2001; 175:28–42. 9. Hamadeh HK, Knight BL, Haugen AC, et al. Methapyrilene toxicity: anchorage of pathologic observations to gene expression alterations.

Download PDF sample

Rated 4.00 of 5 – based on 28 votes