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By D. M. Jerina, J. M. Sayer, D. R. Thakker (auth.), Bernard Pullman, Paul O. P. Ts’o, Harry Gelboin (eds.)

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Read or Download Carcinogenesis: Fundamental Mechanisms and Environmental Effects: Proceedings of the Thirteenth Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, April 28 – May 2, 1980 PDF

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Extra resources for Carcinogenesis: Fundamental Mechanisms and Environmental Effects: Proceedings of the Thirteenth Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, April 28 – May 2, 1980

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Acad. Sci. USA 74, pp. 3335-3339. 14. , Harvey, R. , and Weiss, S. : 1979, Proc. Natl. Acad. Sci. USA 76, pp. 620-624. 15. Cortez, C. and Harvey R. : 1978, Org. Syn. 58, pp. 12-17. 31 POLYCYCLE EPOXIDE INACTIVATION OF VIRAL DNA REPLICATION 16. Harvey, R. , Lee, H. : 1979, J. Org. Chern. 44, pp. 78-83. 17. Sukurnaran, K. S. and Harvey, R. : 1979, J. Arner. Chern. Soc. 101, pp. 1353-1354. 18. Fu, P. P. and Harvey, R. : 1979, J. Org. Chern. 44, pp. 3778-3784. 19. Lee, H. M. and Harvey, R. J. Org. Chern.

29 example, alkylation on the N-7 of guanosine, for which there is precedent (24), could result in depurination leading to mutation. SUMMARY AND CONCLUSIONS The results of the foregoing studies are significant, we believe, with respect to the mechanism of hydrocarbon tumorigenesis. The experiments with o X17 4 DNA show that anti-BPDE efficiently alkylates single-stranded viral DN A, rendering it noninfectious. One molecule of bound diol epoxide appears sufficient to inhibit the replication of a single molecule of 0 X DNA.

Fu, P. , Harvey, R. , and Weiss, S. : 1979, Biochern. Biophys. Res. Cornrnun. 88, pp. 251-257. 23. Chang, G. , Harvey, R. , Hsu, W. , and Weiss, S. : 1979, Biochern. Siophys. Res. Cornrnun. 88, pp. 688-695. 24. Osborne, M. , Harvey, R. : Interact. 20, pp. 123-130. 25. Harvey, R. : 1980, "Safe Handling of Chemical Carcinogens, Mutagens, Teratogens, and Highly Toxic Substances", Walters, D. , Vol. 2, Chap. 23, pp. 439-468. -Biol. DIHYDRODIOLS AND DIOL-EPOXIDES IN THE ACTIVATION AND DETOXIFICATION OF POLYCYCLIC HYDROCARBONS Peter Sims Chester Beatty Research Institute, Institute of Cancer Research:Royal Cancer Hospital, Fulham Road, London SW3 6JB, England.

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