By William Montagna, Richard L. Dobson
Advances in Biology of pores and skin, quantity VII: Carcinogenesis covers court cases of the fifteenth Symposium at the Biology of epidermis, held on the Oregon neighborhood Primate learn middle on April September 11, 1965, lower than the auspices of the collage of Oregon clinical tuition.
This booklet consists of 19 chapters, and starts off with the mechanism of tissue homeostasis in grownup mammals and the kinetics of epidermal response to carcinogenic brokers and different epidermis irritants. The succeeding chapters take care of the expansion selling results of tumors on tissues, the response trend differences among common and neoplastic epithelium, and a few organic implications of chemical carcinogenesis. substantial chapters are dedicated to numerous cancer agents, together with hydrocarbons, viruses, androgens, and estrogens. different chapters examine the physicochemical mechanisms of acceleration of dermis carcinogenesis and experimental observations of environmental carcinogenesis. The mechanisms of dermis melanoma induction as a result of ultraviolet radiation, in addition to arsenic brought on tumors are tested. The concluding chapters describe a few kinds of epidermis tumors, corresponding to adnexal tumors and basal cellphone epithelioma.
This ebook will end up important to oncologists and researchers within the box of carcinogenesis.
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Extra info for Carcinogenesis. Proceedings of a Symposium on the Biology of Skin Held at the University of Oregon Medical School, 1965
KINETICS OF EPIDERMAL REACTION FIG. 2 The keratotome arrangement to remove epidermis. The mouse skin is stretched on a rubber pillow. 200 E ^ 150 a. c Έ ,_100 Q. "c 3 5°1 2 3 4 5 6 7 8 9 10 Time in days after injection FIG. 3 The H3-DNA activity in an untreated epidermal specimen the first 10 days after one single intraperitoneal injection of 50 μ& H3T. 41 42 OLAV HILMAR IVERSEN E. Method of Applying the Substances The skin of the back of the animal was stretched with special forceps (Fig. 4). A metal ring was gently pressed against the double skin flap which rested on a pillow of rubber sponge.
Exp. Cell Res. 35,119-131. YAFFE, D . and FELDMAN, M. (1964). The effect of actinomycin D on heart and thigh muscle cells grown in vitro. Devel. Biol. 9, 347-366. CHAPTER IT KINETICS OF EPIDERMAL REACTION TO CARCINOGENS AND OTHER SKIN IRRITANTS* OLAV HILMAR IVERSENI Institutt for Generell og Eksperimentell Patologi, Universitetet i Oslo, Rikshospitalet, Oslo l% Norway I. INTRODUCTION There is nothing static in biology. As expressed in the Heraclitian principle, "We can never look twice at the same river", so we can never look twice at the same epidermis.
Nature 205, 573-578. BURCH, P. R. J. (1963). Human cancer: Mendelian inheritance or vertical transmission. Nature 197, 1042-1045. BURNET, F. M. (1965). Somatic mutation and chronic disease. Brit. Med. J. (i), 338-342. BUTLER, J. A. V. (1965). Role of histones and other proteins in gene control. Nature 207, 1041-1042. CAFFERY, J. , WHICHARD, L. and IRVIN, J. L. (1964). Effect of histones on the induction of two liver enzymes by hydrocortisone. Arch. Biochem. Biophys. 108, 364-365. CAMERON, I. L.