Sylke M?ller, Rachel Cerdan, Ovidiu Radulescu, Paul M.'s Comprehensive Analysis of Parasite Biology: From Metabolism PDF

By Sylke M?ller, Rachel Cerdan, Ovidiu Radulescu, Paul M. Selzer

Written and edited through specialists within the box, this ebook brings jointly the present cutting-edge in phenotypic and rational, target-based methods to drug discovery opposed to pathogenic protozoa. The chapters concentration rather on digital compounds and excessive throughput screening, common items, computer-assisted drug layout, structure-based drug layout, mechanism of motion identity, and pathway modelling. in addition, state-of the artwork "omics" applied sciences are defined and at present studied enzymatic drug goals are mentioned. Mathematical, structures biology-based methods are brought as new methodologies for dissecting complicated features of pathogen survival mechanisms and for objective id. additionally, lately built anti-parasitic brokers concentrating on specific pathways, which function lead compounds for extra drug improvement, are provided.

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32. minicircles promoted by antitrypanosomal drugs. Proc. Natl. Acad. Sci. , 87, 950–954. G. (2002) Metabolism and distribution of phenanthridine trypanocides in Trypanosoma brucei. , 84, 219–228. , and Zilberstein, D. (1995) The accumulation and compartmentalization of isometamidium chloride in Trypanosoma congolense, monitored by its intrinsic fluorescence. Biochem. , 312(Pt. 1), 319–327. H. (1991) Reduced accumulation of isometamidium by drug-resistant Trypanosoma congolense. Parasitology, 103(Pt.

47. 48. 49. 50. P. (2014) Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery. MedChemComm, 5, 655–658. P. et al. (2011) The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes. Mol. , 80, 110–116. S. H. (1993) Arsenical-resistant trypanosomes lack an unusual adenosine transporter. Nature, 361, 173–176. H. (1995) Uptake of diamidine drugs by the P2 nucleoside transporter in melarsen-sensitive and -resistant Trypanosoma brucei brucei.

32. minicircles promoted by antitrypanosomal drugs. Proc. Natl. Acad. Sci. , 87, 950–954. G. (2002) Metabolism and distribution of phenanthridine trypanocides in Trypanosoma brucei. , 84, 219–228. , and Zilberstein, D. (1995) The accumulation and compartmentalization of isometamidium chloride in Trypanosoma congolense, monitored by its intrinsic fluorescence. Biochem. , 312(Pt. 1), 319–327. H. (1991) Reduced accumulation of isometamidium by drug-resistant Trypanosoma congolense. Parasitology, 103(Pt.

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