Download e-book for kindle: Comprehensive Toxicology, Second Edition by Charlene McQueen

By Charlene McQueen

An explosive elevate within the wisdom of the results of chemical and actual brokers on organic structures has ended in an elevated figuring out of ordinary mobile capabilities and the results in their perturbations. The 14-volume moment variation of Comprehensive Toxicology has been revised and up-to-date to mirror new advances in toxicology examine, together with content material by way of the various top researchers within the box. It is still the optimum source for toxicologists in academia, drugs, and firms.

Comprehensive Toxicology moment Edition presents a different organ-systems constitution that permits the person to discover the poisonous results of varied elements on every one human approach, helping in delivering diagnoses and proving crucial in occasions the place the poisonous substance is unknown yet its results on a approach are noticeable. Comprehensive Toxicology moment Edition is the main whole and worthy toxicology paintings to be had to researchers this day.

  • Contents up to date and revised to mirror advancements in toxicology study
  • Organized with a special organ-system process
  • Features complete colour all through
  • Available electronically on sciencedirect.com, in addition to in a limited-edition print model

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Sample text

The metabolic fate of a chemical can also have an important effect on its disposition in the body and its excretion. There are a number of pathways for the body to biotransform a toxic chemical. These pathways are all mediated by specialized proteins (enzymes) in the cells, which are designed for the purpose of converting unwanted, foreign chemicals to nontoxic metabolites. The products of metabolism are typically more water soluble than the original compound, and are thus more easily excreted.

This integrative approach is called ‘Systems Biology’ (Weston and Hood 2004). Because each level of analysis generates a very large quantity of data, the collection, organization, evaluation, and statistical analysis is in itself an enormous undertaking. The field of ‘Bioinformatics’ has been developed to address the many computational and statistical challenges of ‘omics’ data. In the field of toxicology, the term ‘toxicogenomics’ is used to define the area of research that ‘‘combines transcript, protein and metabolite profiling with conventional toxicology to investigate the interaction between genes and environmental stress in disease causation’’ (Waters and Fostel 2004).

Absorption of chemicals across the skin (percutaneous or dermal absorption) occurs exclusively by simple diffusion. There is little question that the primary barrier to absorption of chemicals across the skin is the stratum corneum. Upon penetration of the stratum corneum, diffusion through the inner layers of the skin is extremely rapid for most substances. There are many factors which can influence both the rate and the extent of absorption of chemicals across the skin. The single most important one is the integrity of the stratum corneum.

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